When it is harvested fresh, pulsatilla vulgaris comes with a poison warning as it contains potentially irritating and toxic compounds.
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Fresh pulsatilla vulgaris is toxic due to the presence of a substance called ranunculin.19
Pulsatilla in its fresh state is capable of irritating the skin and mucous membranes (including nose, mouth, throat) when it comes into contact with them. Further, fresh pulsatilla can irritate the gastrointestinal tract, kidneys or urinary tract if ingested.20
For this reason, pulsatilla should only ever be used when dried and prepared.
The process of cutting or crushing fresh pulsatilla in the presence of water before freeze-drying stimulates the release of an enzyme which neutralises the toxin.21
Allergic reactions have been reported to pulsatilla. A case of chemical burns was reported after a woman administered a self-massage with freshly chopped pulsatilla, unaware of its toxic properties when fresh.22