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Signs and causes of an underactive thyroid

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Written byLaura Jennings

Dr Shree Datta

Reviewed byDr Shree Datta

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Could your thyroid be behind your low energy, weight changes or brain fog? Let’s talk about the signs and causes of an underactive thyroid

Summary

1What is the thyroid?

It’s a small, butterfly-shaped gland located at the base of your neck that’s responsible for hormones that regulate many of our body’s functions.

2What is an underactive thyroid?

It’s when the thyroid gland doesn’t produce enough T3 and T4 hormones, which can cause many of the body’s processes to slow down.

3Symptoms of an underactive thyroid

They can vary from person to person and often develop slowly over time. Some common ones are fatigue, constipation, low mood and more.

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An underactive thyroid (also known as hypothyroidism) is more common than many people realise, especially in women, yet it often goes unnoticed. As the symptoms can be subtle at first, like low energyweight changes or feeling unusually cold, it’s easy to put them down to everyday life. But over time, these small changes can start to add up.

So how do you know if your thyroid could be playing a role? Here’s a closer look at the signs to watch for, what might be causing them and when it’s worth seeking advice.

What is the thyroid?

The thyroid is a small, butterfly-shaped gland located at the base of your neck.2 It forms part of the endocrine system, which is responsible for producing hormones that regulate many of our body’s functions.3 One of the thyroid’s main roles is to support metabolism, which is how your body converts food into energy. It does this by producing two key hormones called thyroxine (T4) and triiodothyronine (T3).1 These hormones influence energy levels, body temperature, heart rate and how efficiently your body uses nutrients.1

What is an underactive thyroid?

An underactive thyroid happens when the thyroid gland doesn’t produce enough T3 and T4 hormones, which can cause many of the body’s processes to slow down.4 It’s estimated that around 2% of people in the UK are affected, with women making up the majority of that percentage.3

Common symptoms of an underactive thyroid

Symptoms of an underactive thyroid can vary from person to person and often develop slowly over time. Common signs of an underactive thyroid include:5
These symptoms are non-specific, meaning they can overlap with other conditions.5 However, experiencing several of them together may suggest the need for further investigation.

When should you speak to a GP?

If you’re experiencing persistent or multiple symptoms, particularly fatigue, weight changes or irregular periods, it’s important to speak to your GP. A healthcare professional can assess your symptoms and if appropriate, arrange tests to check your thyroid function.

Causes of an underactive thyroid

There are several possible causes of an underactive thyroid but the most common include:4,10

Autoimmune conditions

This is where the immune system mistakenly attacks the thyroid gland, affecting its ability to produce hormones.
 

Previous thyroid treatment

Treatments such as thyroid surgery or radioactive iodine therapy can reduce thyroid function over time.
 

Iodine deficiency

Iodine is a mineral needed to produce thyroid hormones. While deficiency is uncommon in the UK, it can still contribute in some cases.
 

Medications

Some medications may affect thyroid function, including those used for certain heart conditions, mental health conditions or cancer treatment.
 

Pituitary gland disorders

The pituitary gland helps regulate thyroid hormone production. Issues affecting this gland can sometimes lead to reduced thyroid activity.
 

Hormonal changes

Hormonal shifts during and after pregnancy, for example, can temporarily affect thyroid function in some people.
 

How is an underactive thyroid diagnosed?

An underactive thyroid is typically assessed through a blood test.4 This test measures levels of thyroid-stimulating hormone and thyroid hormones, helping healthcare professionals determine whether the thyroid is functioning as expected.4

Supporting your overall wellbeing with an underactive thyroid

While an underactive thyroid requires medical assessment, general lifestyle habits can play a role in supporting overall health and how you feel day to day. For example, getting enough sleepmanaging stress and eating a balanced diet can help support energy levels, mood and metabolic health, all of which may be affected when thyroid function is low.6,7,8,9 However, these approaches aren’t a substitute for medical care, so if you suspect a thyroid issue, it’s important to speak to your GP.

Underactive thyroid FAQs

What are the early signs of an underactive thyroid?

Early signs can include fatigue, feeling cold more easily, dry skin and subtle weight gain. These symptoms often develop gradually.10
 

Can hypothyroidism cause digestive issues?

Yes, slowed metabolism can affect digestion, which may contribute to constipation in some people.10
 

Is weight gain always linked to thyroid issues?

Not necessarily. While an underactive thyroid can contribute to weight gain, many other factors can also influence body weight.11
 

Can stress affect thyroid function?

Stress doesn’t directly cause an underactive thyroid, but long-term stress can influence hormonal balance and overall wellbeing.8,12
 

The final say

An underactive thyroid can quietly influence everything from your energy levels to how your body manages weight, often in ways that aren’t immediately obvious. As the symptoms can be subtle and overlap with other conditions, it’s important not to jump to conclusions or self-diagnose.

If something doesn’t feel quite right, speaking to your GP is the best place to start – they can help you get clarity and the right support. Alongside medical guidance, small lifestyle habits can also make a meaningful difference. Building a consistent exercise routine and supporting your gut health both simple, positive steps that can help you feel more in control of your wellbeing.
Disclaimer – This article provides informational advice and is not a substitute for medical care. Working with experts for accuracy, we take great care to ensure the information is up-to-date and relevant. However, you should always consult your GP or healthcare professional before using supplements or alternative products, particularly if you have medical conditions or are under supervision.

Sources

1. Sabatino L, Vassalle C. Thyroid Hormones and Metabolism Regulation: Which Role on Brown Adipose Tissue and Browning Process? Biomolecules. 2025; 15(3):361. https://www.mdpi.com/2218-273X/15/3/361#article-metrics-citations
2. Khan YS, Farhana A. Histology, thyroid gland. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; January 2026. Updated May 1, 2025. https://www.ncbi.nlm.nih.gov/books/NBK551659/
3. Das D, Banerjee A, Jena AB, Duttaroy AK, Pathak S. Essentiality, relevance, and efficacy of adjuvant/combinational therapy in the management of thyroid dysfunctions. Biomed Pharmacother. 2022 Feb;146:112613. https://pubmed.ncbi.nlm.nih.gov/35062076/
4. Patil N, Rehman A, Anastasopoulou C, et al. Hypothyroidism. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; January 2026. Updated February 18, 2024. https://www.ncbi.nlm.nih.gov/books/NBK519536/
5. Shahid MA, Ashraf MA, Sharma S. Physiology, thyroid hormone. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; January 2026. Updated June 5, 2023. https://www.ncbi.nlm.nih.gov/books/NBK500006/
6. Nazem MR, Bastanhagh E, Emami A, Hedayati M, Samimi S, Karami M. The relationship between thyroid function tests and sleep quality: cross-sectional study. Sleep Sci. 2021 Jul-Sep;14(3):196-200. https://pmc.ncbi.nlm.nih.gov/articles/PMC8848531/#abstract1
7. Sharma S, Kavuru M. Sleep and metabolism: an overview. Int J Endocrinol. 2010;2010:270832. https://pmc.ncbi.nlm.nih.gov/articles/PMC2929498/
8. Singh M, Narayan J, Thakur R, Bhattacharya S, Sonkar SK, Ali W. Association of stress and primary hypothyroidism. J Family Med Prim Care. 2024 Mar;13(3):1073-1078. https://pmc.ncbi.nlm.nih.gov/articles/PMC11086806/#sec10
9. Soetedjo NNM. The role of nutrition in various endocrine and metabolic diseases. Clin Nutr Open Sci. 2025;62:164-188. https://www.sciencedirect.com/science/article/pii/S2667268525000646
10. NHS. Underactive thyroid (hypothyroidism). NHS website. Reviewed April 28, 2025. Accessed March 19, 2026. https://www.nhs.uk/conditions/underactive-thyroid-hypothyroidism/
11. Aurangabadkar G, Boddu SK. Hypothyroidism and obesity: Is there a bidirectional link? What is the impact on our clinical practice? Thyroid Res Pract. 2020;17(3):118-122. https://journals.lww.com/trap/fulltext/2020/17030/hypothyroidism_and_obesity__is_there_a.5.aspx
12. Ranabir S, Reetu K. Stress and hormones. Indian J Endocrinol Metab. 2011 Jan;15(1):18-22. https://pmc.ncbi.nlm.nih.gov/articles/PMC3079864/
 

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